NSAID-Nebenwirkungen bei Hund und Katze – Wie häufig und was tun?

Falsch angewendet können NSAID mit erheblichen, zum Teil lebensbedrohlichen Nebenwirkungen einhergehen. Der Beitrag informiert über pharmakologische Hintergründe, typische Nebenwirkungen und die therapeutische Versorgung im Falle einer Intoxikation.

Publication History

Article published online:
23 June 2020

• Literatur

• 1 McLean MK, Khan SA. Toxicology of frequently encountered nonsteroidal anti-inflammatory drugs in dogs and cats: an update. Vet Clin North Am Small Anim Pract 2018; 48 (06) 969-984
• 2 Potter M, Macintire DK. NSAID toxicity in dogs. Comp Small Anim Pract 2008; 10 (10) 8-12
• 3 Knapp DW, Glickman NW, Widmer WR. et al. Cisplatin versus cisplatin combined with piroxicam in a canine model of human invasive urinary bladder cancer. Cancer Chemother Pharmacol 2000; 46 (03) 221-226
• 4 Saito T, Tamura D, Asano R. Usefulness of selective COX-2 inhibitors as therapeutic agents against canine mammary tumors. Oncol Rep 2014; 31 (04) 1637-1644
• 5 Narita T, Sato R, Motoishi K. et al. The interaction between orally administered non-steroidal anti-inflammatory drugs and prednisolone in healthy dogs. J Vet Med Sci 2007; 69 (04) 353-363
• 6 Lascelles BD, Blikslager AT, Fox SM. et al. Gastrointestinal tract perforation in dogs treated with a selective cyclooxygenase-2 inhibitor: 29 cases (2002–2003). J Am Vet Med Assoc 2005; 227 (07) 1112-1117
• 7 Veterinärmedizinischer Informationsdienst für Arzneimittelanwendung, Toxikologie und Arzneimittelrecht. Im Internet (Stand: November 2019): http://www.vetidata.de
• 8 Löscher W, Richter A, Potschka H. Hrsg. Pharmakotherapie bei Haus- und Nutztieren. 9. Aufl.. Stuttgart: Enke; 2014
• 9 Hsu WH. Handbook of Veterinary Pharmacology. 2^nd ed. Arnes: Wiley; 2013
• 10 Mealey KL. Pharmacotherapeutics for Veterinary Dispensing. Hoboken: Wiley Blackwell; 2019
• 11 Gupta RC. Veterinary Toxicology: Basic and Clinical Principles. 3^rd ed. Amsterdam: Academic Press; 2018
• 12 Fritzenschaft N. Unerwünschte Arzneimittelwirkungen selektiver Cyclooxygenase-2-Hemmstoffe bei Hund und Katze [Dissertation]. München: Ludwig-Maximilians-Universität München; 2017
• 13 Jasiecka-Mikolajczyk A, Maślanka T, Jaroszewkski JJ. Pharmacological characteristics of metamizole. Pol J Vet Sci 2014; 17 (01) 207-214
• 14 Wooten JG, Blikslager AT, Ryan KA. et al. Cyclooxygenase expression and prostanoid production in pyloric and duodenal mucosae in dogs after administration of nonsteroidal anti-inflammatory drugs. Am J Vet Res 2008; 69 (04) 457-464
• 15 Ng LE, Halliwell B, Wong KP. Nephrotoxic cell death by diclofenac and meloxicam. Biochem Biophys Res Commun 2008; 369 (03) 873-878
• 16 Mullins KB, Thomason JM, Lunsford KV. et al. Effects of carprofen, meloxicam and deracoxib on platelet function in dogs. Vet Anaesth Analg 2012; 39 (02) 206-217
• 17 Khan S, Andrews KL, Chin-Dusting JPF. Cyclo-oxygenase (COX) inhibitors and cardiovascular risk: are non-steroidal anti-inflammatory drugs really anti-inflammatory?. Int J Mol Sci 2019; 20 (17) 4262
• 18 Lees P, Pelligand L, Elliott J. et al. Pharmacokinetics, pharmacodynamics, toxicology and therapeutics of mavacoxib in the dog: a review. J Vet Pharmacol Ther 2015; 38 (01) 1-14
• 19 Kongara K, Chambers JP. Robenacoxib in the treatment of pain in cats and dogs: safety, efficacy, and place in therapy. Vet Med (Auckl) 2018; 9: 53-61
• 20 McFarland SE, Mischke RH, Hopster-Iversen C. et al. Systematic account of animal poisonings in Germany, 2012–2015. Vet Rec 2017; 180 (13) 327
• 21 Rostom A, Muir K, Dube C. et al. Prevention of NSAID-related upper gastrointestinal toxicity: a meta-analysis of traditional NSAID with gastroprotection and COX-2 inhibitors. Drug Healthc Patient Saf 2009; 1: 47-71
• 22 Wallace JL, Syer S, Denou E. et al. Proton pump inhibitors exacerbate NSAID-induced small intestinal injury by inducing dysbiosis. Gastroenterology 2011; 141 (04) 1314-1322
• 23 Marks SL, Kook PH, Papich MG. et al. ACVIM concensus statement: support for rational administration of gastrointestinal protectants to dogs and cats. J Vet Intern Med 2018; 32 (06) 1823-1840